Human Skin Cells rejuvenated 30 years with New Reverse Aging method

Researchers in the UK have made a way to reverse the aging process in skin cells which helps turning back the biological clock for about 30 years.

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Researchers in the UK have made a way to reverse the aging process in skin cells which helps turning back the biological clock for about 30 years.

Human Skin Cells rejuvenated 30 years with New Reverse Aging method

Reversing the aging process in skin cells have become increasingly popular over the past decade, with the researchers reprogramming many types of mouse and human cells. But never before have cells aged so many years still retain their function.

The reverse aging method was developed by Diljeet Gill who is doing postdoctoral research at the Babraham Institute in Cambridge, England with his colleagues. The study was published on April 8 in the journal eLife.

The researchers applied the technique to fibroblasts (a common type of skin cell) from three middle-aged people who are averagely about 50 years old, then compare them with younger cells from people aged 20 to 22.

The researchers found that older cells are similar to younger cells, both chemically and genetically. Upon further exploration, the research team even found that the technique affected genes involved in age-related diseases such as Alzheimer's disease and cataracts.

Moreover, Gill and colleagues looked at the activity of fibroblasts to determine if they could behave like young skin cells. When they injured a layer of cells, they found that the rejuvenated cells quickly moved to fill the gap - much like how young cells work when healing a wound.

Partly reprogrammed cells, like the skin cells in Gill's study, become biologically younger and retain specialized cellular functions, although they may still carry a potential cancer risk.

Ben Van Handel, a stem cell biologist and co-founder of skin care company Heraux and biopharmaceutical company CarthroniX, says that this reverse aging technology will never be used in a clinical setting because it is currently a type of gene therapy that is not possible in humans. There is still a lot of concern about these cells becoming cancerous and controlling the rejuvenation process.

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