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A PDE9 INHIBITOR TO REDUCE OBESITY WAS FOUND



Researchers at Johns Hopkins Medicine have discovered an enzyme inhibitor PDE9 that stimulates fat-burning cells and may reduce obesity.

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Researchers at Johns Hopkins Medicine have discovered an enzyme inhibitor PDE9 that stimulates fat-burning cells and may reduce obesity.

PDE9 enzyme inhibitors stimulate fat burning cells to reduce fat.  According to scientists at Johns Hopkins University School of Medicine, currently, there is no effective-proven drug to treat obesity.  The chemical inhibitor of the enzyme PDE9 was found that activates fat burning to reduce obesity and fat accumulation in the liver and heart.


A PDE9 inhibitor to Reduce Obesity was foundA PDE9 inhibitor to Reduce Obesity was found / ph: pexels 

Research from 2015 has shown that the enzyme PDE9 is present in the heart and contributes to heart disease due to hypertension.  Thus, blocking PDE9 increases the amount of a small molecule (the GMP ring), which in turn controls cellular function throughout the body.  A chemical inhibitor of the enzyme PDE9 stimulates cells to burn more fat.

Researchers have also found that PDE9 inhibitors can improve cardiovascular syndrome (CMS), including hypertension, hyperglycemia, cholesterol and high blood triglycerides, and excess body fat, especially around the waist.  

Health professionals view CMS as a pandemic and a major risk factor for heart disease, stroke, type 2 diabetes, cancer,..

According to researchers, if being used in humans, a person weighing about 113 kg could lose 23 kg with an oral PDE9 inhibitor without needing to change their eating or exercise habits.

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When both diet and exercise are combined, the effects of the drug can be even greater.

The scientists will find out if PDE9 inhibitors have the same effects in postmenopausal men and women.

A PDE9 INHIBITOR TO REDUCE OBESITY WAS FOUND

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